Efficient Route toC2Symmetric Heterocyclic Backbone Modified Cyclic Peptides

Backbone-modified amphiphilic cyclic di- and tetrasaccharides.

Synthesis of amphiphilic, cyclic di- and tetrasaccharides, which incorporate a methylene moiety at the inter-glycosidic bond, is reported. The amphiphilic properties of the new cyclic tetrasaccharide host were identified through assessing the solubilities of guests in aqueous and in organic solvents. The glycosidic bond stability of the cyclic tetrasaccharide under aqueous acidic condition was ...

Backbone-modified analogues of small peptides: transport and antibacterial activity.

Payne, J. W. & Bell, G. (1979)J. Bacteriol. 137,447-455 Payne. J. W. & Nisbet. T. M. (1981) J . Appl . Biochem. 3. 447Payne, J. W. & Gilvarg, C. (1971) Adu. Enzymol. Relai. Areas Mol. Payne, J. W., Payne. G . M. & Nisbet, T. M. (1982) FEMS Microbiol. Payne, J. W. & Gilvarg, C . (1978) in Bacierial Transport (Rosen, Ringrose, P. S. (1980) in Microorganisms and Nitrogen Sources Payne, J. W. & Nis...

Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview abou...

Efficient Monte Carlo Methods for Cyclic Peptides

We present a new, biased Monte Carlo scheme for simulating complex, cyclic peptides. Backbone atoms are equilibrated with a biased rebridging scheme, and side-chain atoms are equilibrated with a look-ahead configurational bias Monte Carlo. Parallel tempering is shown to be an important ingredient in the construction of an efficient approach. Submitted to Molecular Physics.